Plasmodium falciparum Parasites Are Killed by a Transition State Analogue of Purine Nucleoside Phosphorylase in a Primate Animal Model

Plasmodium falciparum causes most of the one million annual deaths from malaria. Drug resistance is widespread and novel agents against new targets are needed to support combination-therapy approaches promoted by the World Health Organization. Plasmodium species are purine auxotrophs. Blocking purin...

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Detalles Bibliográficos
Main Authors: Cassera, María B., Hazleton, Keith Z., Merino, Emilio F., Obaldia, Nicanor, Ho, Meng-Chiao, Murkin, Andrew S., DePinto, Richard, Gutierrez, Jemy A., Almo, Steven C., Evans, Gary B., Babu, Yarlagadda S., Schramm, Vern L.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2011
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3214022/
https://ncbi.nlm.nih.gov/pubmed/22096507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0026916
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