CIIA functions as a molecular switch for the Rac1-specific GEF activity of SOS1

Son of sevenless 1 (SOS1) is a dual guanine nucleotide exchange factor (GEF) that activates the guanosine triphosphatases Rac1 and Ras, which mediate signaling initiated by peptide growth factors. In this paper, we show that CIIA is a new binding partner of SOS1. CIIA promoted the SOS1–Rac1 interact...

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Autori principali: Hwang, Hyun Sub, Hwang, Sang Gil, Cho, Jun-Ho, Chae, Ji Soo, Yoon, Kyoung Wan, Cho, Ssang-Goo, Choi, Eui-Ju
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2011
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3206349/
https://ncbi.nlm.nih.gov/pubmed/22042618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201106138
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