Phosphorylation of SOS1 on tyrosine 1196 promotes its RAC GEF activity and contributes to BCR-ABL leukemogenesis

Son of Sevenless 1 (SOS1) is a dual guanine nucleotide exchange factor (GEF) that activates the small GTPases RAC and RAS. Although the molecular mechanisms of RAS GEF catalysis have been unveiled, how SOS1 acquires RAC GEF activity and what is the physio-pathological relevance of this activity is m...

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Publicat a:Leukemia
Autors principals: Gerboth, S, Frittoli, E, Palamidessi, A, Baltanas, F C, Salek, M, Rappsilber, J, Giuliani, C, Troglio, F, Rolland, Y, Pruneri, G, Kreutmair, S, Pallavicini, I, Zobel, M, Cinquanta, M, Minucci, S, Gomez, C, Santos, E, Illert, A L, Scita, G
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2018
Matèries:
Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5739283/
https://ncbi.nlm.nih.gov/pubmed/28819285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2017.267
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