An effector region in Eps8 is responsible for the activation of the Rac-specific GEF activity of Sos-1 and for the proper localization of the Rac-based actin–polymerizing machine

Genetic and biochemical evidence demonstrated that Eps8 is involved in the routing of signals from Ras to Rac. This is achieved through the formation of a tricomplex consisting of Eps8–E3b1–Sos-1, which is endowed with Rac guanine nucleotide exchange activity. The catalytic subunit of this complex i...

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Main Authors: Scita, Giorgio, Tenca, Pierluigi, Areces, Liliana B., Tocchetti, Arianna, Frittoli, Emanuela, Giardina, Giuseppina, Ponzanelli, Isabella, Sini, Patrizia, Innocenti, Metello, Di Fiore, Pier Paolo
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2001
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2196181/
https://ncbi.nlm.nih.gov/pubmed/11524436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200103146
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