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Mechanisms through which Sos-1 coordinates the activation of Ras and Rac
Signaling from receptor tyrosine kinases (RTKs)* requires the sequential activation of the small GTPases Ras and Rac. Son of sevenless (Sos-1), a bifunctional guanine nucleotide exchange factor (GEF), activates Ras in vivo and displays Rac-GEF activity in vitro, when engaged in a tricomplex with Eps...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
The Rockefeller University Press
2002
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2173577/ https://ncbi.nlm.nih.gov/pubmed/11777939 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200108035 |
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