Sos-mediated activation of rac1 by p66shc

The Son of Sevenless 1 protein (sos1) is a guanine nucleotide exchange factor (GEF) for either the ras or rac1 GTPase. We show that p66shc, an adaptor protein that promotes oxidative stress, increases the rac1-specific GEF activity of sos1, resulting in rac1 activation. P66shc decreases sos1 bound t...

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Detalhes bibliográficos
Main Authors: Khanday, Firdous A., Santhanam, Lakshmi, Kasuno, Kenji, Yamamori, Tohru, Naqvi, Asma, DeRicco, Jeremy, Bugayenko, Artem, Mattagajasingh, Ilwola, Disanza, Andrea, Scita, Giorgio, Irani, Kaikobad
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2006
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2063726/
https://ncbi.nlm.nih.gov/pubmed/16520382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200506001
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