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Transcriptional repression of Kruppel like factor-2 by the adaptor protein p66shc

The adaptor protein p66shc promotes cellular oxidative stress and apoptosis. Here, we demonstrate a novel mechanistic relationship between p66shc and the kruppel like factor-2 (KLF2) transcription factor and show that this relationship has biological relevance to p66shc-regulated cellular oxidant le...

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Autors principals: Kumar, Ajay, Hoffman, Timothy A., DeRicco, Jeremy, Naqvi, Asma, Jain, Mukesh K., Irani, Kaikobad
Format: Artigo
Idioma:Inglês
Publicat: The Federation of American Societies for Experimental Biology 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812051/
https://ncbi.nlm.nih.gov/pubmed/19696221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-138743
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