Epigenetic upregulation of p66shc mediates low-density lipoprotein cholesterol-induced endothelial cell dysfunction

Hypercholesterolemia characterized by elevation of low-density lipoprotein (LDL) cholesterol is a major risk factor for atherosclerotic vascular disease. p66shc mediates hypercholesterolemia-induced endothelial dysfunction and atheromatous plaque formation. We asked if LDL upregulates endothelial p6...

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Detalhes bibliográficos
Main Authors: Kim, Young-Rae, Kim, Cuk-Seong, Naqvi, Asma, Kumar, Ajay, Kumar, Santosh, Hoffman, Timothy A., Irani, Kaikobad
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2012
Assuntos:
Vascular Biology and Microcirculation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3404699/
https://ncbi.nlm.nih.gov/pubmed/22661506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.01218.2011
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