Sirtuin1-regulated lysine acetylation of p66Shc governs diabetes-induced vascular oxidative stress and endothelial dysfunction

The 66-kDa Src homology 2 domain-containing protein (p66Shc) is a master regulator of reactive oxygen species (ROS). It is expressed in many tissues where it contributes to organ dysfunction by promoting oxidative stress. In the vasculature, p66Shc-induced ROS engenders endothelial dysfunction. Here...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Kumar, Santosh, Kim, Young-Rae, Vikram, Ajit, Naqvi, Asma, Li, Qiuxia, Kassan, Modar, Kumar, Vikas, Bachschmid, Markus M., Jacobs, Julia S., Kumar, Ajay, Irani, Kaikobad
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5321021/
https://ncbi.nlm.nih.gov/pubmed/28137876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1614112114
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