P66Shc-induced MicroRNA-34a Causes Diabetic Endothelial Dysfunction by Downregulating Sirtuin1

OBJECTIVE: Diabetes mellitus causes vascular endothelial dysfunction and alters vascular microRNA expression. We investigated if endothelial microRNA-34a (miR-34a) leads to diabetic vascular dysfunction by targeting endothelial Sirtuin1 (Sirt1), and asked if the oxidative stress protein p66Shc gover...

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Publicado en:Arterioscler Thromb Vasc Biol
Autores principales: Li, Qiuxia, Kim, Young-Rae, Vikram, Ajit, Kumar, Santosh, Kassan, Modar, Gabani, Mohanad, Lee, Sang Ki, Jacobs, Julia S, Irani, Kaikobad
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5293179/
https://ncbi.nlm.nih.gov/pubmed/27789474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.116.308321
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