SIRT1 deacetylates APE1 and regulates cellular base excision repair

Apurinic/apyrimidinic endonuclease-1 (APE1) is an essential enzyme in the base excision repair (BER) pathway. Here, we show that APE1 is a target of the SIRTUIN1 (SIRT1) protein deacetylase. SIRT1 associates with APE1, and this association is increased with genotoxic stress. SIRT1 deacetylates APE1...

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Detalhes bibliográficos
Main Authors: Yamamori, Tohru, DeRicco, Jeremy, Naqvi, Asma, Hoffman, Timothy A., Mattagajasingh, Ilwola, Kasuno, Kenji, Jung, Saet-Byel, Kim, Cuk-Seong, Irani, Kaikobad
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2817463/
https://ncbi.nlm.nih.gov/pubmed/19934257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp1039
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