Redox Factor-1 Activates Endothelial SIRTUIN1 through Reduction of Conserved Cysteine Sulfhydryls in Its Deacetylase Domain

Apurinic/Apyrmidinic Endonuclease 1/Redox Factor-1 (APE1/Ref-1) is a reductant which is important for vascular homeostasis. SIRTUIN1 (SIRT1) is a lysine deacetylase that also promotes endothelium-dependent vasorelaxation. We asked if APE1/Ref-1 governs the redox state and activity of SIRT1, and whet...

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Hlavní autoři: Jung, Saet-Byel, Kim, Cuk-Seong, Kim, Young-Rae, Naqvi, Asma, Yamamori, Tohru, Kumar, Santosh, Kumar, Ajay, Irani, Kaikobad
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3670896/
https://ncbi.nlm.nih.gov/pubmed/23755229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0065415
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