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A single-nucleotide variation in a p53-binding site affects nutrient-sensitive human SIRT1 expression
The SIRTUIN1 (SIRT1) deacetylase responds to changes in nutrient availability and regulates mammalian physiology and metabolism. Human and mouse SIRT1 are transcriptionally repressed by p53 via p53 response elements in their proximal promoters. Here, we identify a novel p53-binding sequence in the d...
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| Main Authors: | , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2951863/ https://ncbi.nlm.nih.gov/pubmed/20693263 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq331 |
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