A single-nucleotide variation in a p53-binding site affects nutrient-sensitive human SIRT1 expression

The SIRTUIN1 (SIRT1) deacetylase responds to changes in nutrient availability and regulates mammalian physiology and metabolism. Human and mouse SIRT1 are transcriptionally repressed by p53 via p53 response elements in their proximal promoters. Here, we identify a novel p53-binding sequence in the d...

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Main Authors: Naqvi, Asma, Hoffman, Timothy A., DeRicco, Jeremy, Kumar, Ajay, Kim, Cuk-Seong, Jung, Saet-Byel, Yamamori, Tohru, Kim, Young-Rae, Mehdi, Fardeen, Kumar, Santosh, Rankinen, Tuomo, Ravussin, Eric, Irani, Kaikobad
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2010
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Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2951863/
https://ncbi.nlm.nih.gov/pubmed/20693263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq331
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