Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice

Bone morphogenetic protein (BMP) signaling induces hepatic expression of the peptide hormone hepcidin. Hepcidin reduces serum iron levels by promoting degradation of the iron exporter ferroportin. A relative deficiency of hepcidin underlies the pathophysiology of many of the genetically distinct iro...

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Main Authors: Steinbicker, Andrea U., Bartnikas, Thomas B., Lohmeyer, Lisa K., Leyton, Patricio, Mayeur, Claire, Kao, Sonya M., Pappas, Alexandra E., Peterson, Randall T., Bloch, Donald B., Yu, Paul B., Fleming, Mark D., Bloch, Kenneth D.
格式: Artigo
語言:Inglês
出版: American Society of Hematology 2011
主題:
Red Cells, Iron, and Erythropoiesis
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204739/
https://ncbi.nlm.nih.gov/pubmed/21841161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-03-339952
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