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Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice
Bone morphogenetic protein (BMP) signaling induces hepatic expression of the peptide hormone hepcidin. Hepcidin reduces serum iron levels by promoting degradation of the iron exporter ferroportin. A relative deficiency of hepcidin underlies the pathophysiology of many of the genetically distinct iro...
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| Main Authors: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3204739/ https://ncbi.nlm.nih.gov/pubmed/21841161 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-03-339952 |
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