Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice

Bone morphogenetic protein (BMP) signaling induces hepatic expression of the peptide hormone hepcidin. Hepcidin reduces serum iron levels by promoting degradation of the iron exporter ferroportin. A relative deficiency of hepcidin underlies the pathophysiology of many of the genetically distinct iro...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Steinbicker, Andrea U., Bartnikas, Thomas B., Lohmeyer, Lisa K., Leyton, Patricio, Mayeur, Claire, Kao, Sonya M., Pappas, Alexandra E., Peterson, Randall T., Bloch, Donald B., Yu, Paul B., Fleming, Mark D., Bloch, Kenneth D.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society of Hematology 2011
Gaiak:
Red Cells, Iron, and Erythropoiesis
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204739/
https://ncbi.nlm.nih.gov/pubmed/21841161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-03-339952
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