Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice

Bone morphogenetic protein (BMP) signaling induces hepatic expression of the peptide hormone hepcidin. Hepcidin reduces serum iron levels by promoting degradation of the iron exporter ferroportin. A relative deficiency of hepcidin underlies the pathophysiology of many of the genetically distinct iro...

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Detaylı Bibliyografya
Asıl Yazarlar: Steinbicker, Andrea U., Bartnikas, Thomas B., Lohmeyer, Lisa K., Leyton, Patricio, Mayeur, Claire, Kao, Sonya M., Pappas, Alexandra E., Peterson, Randall T., Bloch, Donald B., Yu, Paul B., Fleming, Mark D., Bloch, Kenneth D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Hematology 2011
Konular:
Red Cells, Iron, and Erythropoiesis
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204739/
https://ncbi.nlm.nih.gov/pubmed/21841161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-03-339952
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