Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice

Bone morphogenetic protein (BMP) signaling induces hepatic expression of the peptide hormone hepcidin. Hepcidin reduces serum iron levels by promoting degradation of the iron exporter ferroportin. A relative deficiency of hepcidin underlies the pathophysiology of many of the genetically distinct iro...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Steinbicker, Andrea U., Bartnikas, Thomas B., Lohmeyer, Lisa K., Leyton, Patricio, Mayeur, Claire, Kao, Sonya M., Pappas, Alexandra E., Peterson, Randall T., Bloch, Donald B., Yu, Paul B., Fleming, Mark D., Bloch, Kenneth D.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2011
Assuntos:
Red Cells, Iron, and Erythropoiesis
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204739/
https://ncbi.nlm.nih.gov/pubmed/21841161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-03-339952
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares