Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice

Bone morphogenetic protein (BMP) signaling induces hepatic expression of the peptide hormone hepcidin. Hepcidin reduces serum iron levels by promoting degradation of the iron exporter ferroportin. A relative deficiency of hepcidin underlies the pathophysiology of many of the genetically distinct iro...

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Auteurs principaux: Steinbicker, Andrea U., Bartnikas, Thomas B., Lohmeyer, Lisa K., Leyton, Patricio, Mayeur, Claire, Kao, Sonya M., Pappas, Alexandra E., Peterson, Randall T., Bloch, Donald B., Yu, Paul B., Fleming, Mark D., Bloch, Kenneth D.
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2011
Sujets:
Red Cells, Iron, and Erythropoiesis
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204739/
https://ncbi.nlm.nih.gov/pubmed/21841161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-03-339952
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