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An important role for Akt3 in platelet activation and thrombosis

The Akt family of serine/threonine kinases includes Akt1, Akt2, and Akt3 isoforms. Prior studies have reported that Akt1 and Akt2, but not Akt3, are expressed in platelets. Here, we show that Akt3 is expressed in substantial amounts in platelets. Akt3(−/−) mouse platelets selectively exhibit impaire...

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Bibliografiske detaljer
Main Authors: O'Brien, Kelly A., Stojanovic-Terpo, Aleksandra, Hay, Nissim, Du, Xiaoping
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204738/
https://ncbi.nlm.nih.gov/pubmed/21821713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-12-323204
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