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ADP-Stimulated Activation of Akt During Integrin Outside-in Signaling Promotes Platelet Spreading by Inhibiting Glycogen Synthase Kinase-3β
OBJECTIVE: Integrins mediate platelet adhesion and transmit “outside in” signals, leading to platelet spreading. Phosphoinositide 3-Kinases (PI3Ks) play a critical role in outside-in signaling and platelet spreading; however, the mechanisms of PI3K activation and function in outside-in signaling are...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3447984/ https://ncbi.nlm.nih.gov/pubmed/22814751 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.112.254680 |
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