Peptide LSARLAF induces integrin β3 dependent outside-in signaling in platelets

INTRODUCTION: Peptide LSARLAF (LSA) can bind and activate integrin αIIbβ3 in the absence of ‘inside-out’ signal. The active αIIbβ3 mediates ‘outside-in’ signaling that elicits platelet aggregation, granule secretion and TxA2 production. Here we identify the membrane glycoproteins which mediate LSA-i...

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Main Authors: Niu, Haixia, Xu, Zhenlu, Li, Ding, Zhang, Lin, Wang, Kemin, Taylor, Donald B., Liu, Junling, Gartner, T. Kent
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3393848/
https://ncbi.nlm.nih.gov/pubmed/22482832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.thromres.2012.03.004
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