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Peptide LSARLAF induces integrin β3 dependent outside-in signaling in platelets
INTRODUCTION: Peptide LSARLAF (LSA) can bind and activate integrin αIIbβ3 in the absence of ‘inside-out’ signal. The active αIIbβ3 mediates ‘outside-in’ signaling that elicits platelet aggregation, granule secretion and TxA2 production. Here we identify the membrane glycoproteins which mediate LSA-i...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3393848/ https://ncbi.nlm.nih.gov/pubmed/22482832 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.thromres.2012.03.004 |
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