LIM kinase-1 selectively promotes glycoprotein Ib-IX–mediated TXA(2) synthesis, platelet activation, and thrombosis

Current antithrombotic drugs have an adverse effect on bleeding, highlighting the need for new molecular targets for developing antithrombotic drugs that minimally affect hemostasis. Here we show that LIMK1(−/−) mice have defective arterial thrombosis in vivo but do not differ from wild-type mice wi...

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Detalhes bibliográficos
Main Authors: Estevez, Brian, Stojanovic-Terpo, Aleksandra, Delaney, M. Keegan, O’Brien, Kelly A., Berndt, Michael C., Ruan, Changgeng, Du, Xiaoping
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668491/
https://ncbi.nlm.nih.gov/pubmed/23620575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-12-470765
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