LIM kinase-1 selectively promotes glycoprotein Ib-IX–mediated TXA(2) synthesis, platelet activation, and thrombosis

Current antithrombotic drugs have an adverse effect on bleeding, highlighting the need for new molecular targets for developing antithrombotic drugs that minimally affect hemostasis. Here we show that LIMK1(−/−) mice have defective arterial thrombosis in vivo but do not differ from wild-type mice wi...

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Autori principali: Estevez, Brian, Stojanovic-Terpo, Aleksandra, Delaney, M. Keegan, O’Brien, Kelly A., Berndt, Michael C., Ruan, Changgeng, Du, Xiaoping
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2013
Soggetti:
Thrombosis and Hemostasis
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668491/
https://ncbi.nlm.nih.gov/pubmed/23620575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-12-470765
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