LIM kinase-1 selectively promotes glycoprotein Ib-IX–mediated TXA(2) synthesis, platelet activation, and thrombosis

Current antithrombotic drugs have an adverse effect on bleeding, highlighting the need for new molecular targets for developing antithrombotic drugs that minimally affect hemostasis. Here we show that LIMK1(−/−) mice have defective arterial thrombosis in vivo but do not differ from wild-type mice wi...

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Bibliografische gegevens
Hoofdauteurs: Estevez, Brian, Stojanovic-Terpo, Aleksandra, Delaney, M. Keegan, O’Brien, Kelly A., Berndt, Michael C., Ruan, Changgeng, Du, Xiaoping
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2013
Onderwerpen:
Thrombosis and Hemostasis
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668491/
https://ncbi.nlm.nih.gov/pubmed/23620575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-12-470765
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