LIM kinase-1 selectively promotes glycoprotein Ib-IX–mediated TXA(2) synthesis, platelet activation, and thrombosis

Current antithrombotic drugs have an adverse effect on bleeding, highlighting the need for new molecular targets for developing antithrombotic drugs that minimally affect hemostasis. Here we show that LIMK1(−/−) mice have defective arterial thrombosis in vivo but do not differ from wild-type mice wi...

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Hlavní autoři: Estevez, Brian, Stojanovic-Terpo, Aleksandra, Delaney, M. Keegan, O’Brien, Kelly A., Berndt, Michael C., Ruan, Changgeng, Du, Xiaoping
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2013
Témata:
Thrombosis and Hemostasis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668491/
https://ncbi.nlm.nih.gov/pubmed/23620575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-12-470765
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