LIM kinase-1 selectively promotes glycoprotein Ib-IX–mediated TXA(2) synthesis, platelet activation, and thrombosis

Current antithrombotic drugs have an adverse effect on bleeding, highlighting the need for new molecular targets for developing antithrombotic drugs that minimally affect hemostasis. Here we show that LIMK1(−/−) mice have defective arterial thrombosis in vivo but do not differ from wild-type mice wi...

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Detaylı Bibliyografya
Asıl Yazarlar: Estevez, Brian, Stojanovic-Terpo, Aleksandra, Delaney, M. Keegan, O’Brien, Kelly A., Berndt, Michael C., Ruan, Changgeng, Du, Xiaoping
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Hematology 2013
Konular:
Thrombosis and Hemostasis
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3668491/
https://ncbi.nlm.nih.gov/pubmed/23620575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-12-470765
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