Identification of a juxtamembrane mechanosensitive domain in the platelet mechanosensor glycoprotein Ib-IX complex

How glycoprotein (GP)Ib-IX complex on the platelet surface senses the blood flow through its binding to the plasma protein von Willebrand factor (VWF) and transmits a signal into the platelet remains unclear. Here we show that optical tweezer-controlled pulling of the A1 domain of VWF (VWF-A1) on GP...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Zhang, Wei, Deng, Wei, Zhou, Liang, Xu, Yan, Yang, Wenjun, Liang, Xin, Wang, Yizhen, Kulman, John D., Zhang, X. Frank, Li, Renhao
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2015
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4296016/
https://ncbi.nlm.nih.gov/pubmed/25359992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-07-589507
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