Solution X-ray scattering combined with computational modeling reveals multiple conformations of covalently bound ubiquitin on PCNA

PCNA ubiquitination in response to DNA damage leads to the recruitment of specialized translesion polymerases to the damage locus. This constitutes one of the initial steps in translesion synthesis (TLS)—a critical pathway for cell survival and for maintenance of genome stability. The recent crystal...

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Bibliografiset tiedot
Päätekijät: Tsutakawa, Susan E., Van Wynsberghe, Adam W., Freudenthal, Bret D., Weinacht, Christopher P., Gakhar, Lokesh, Washington, M. Todd, Zhuang, Zhihao, Tainer, John A., Ivanov, Ivaylo
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2011
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3203759/
https://ncbi.nlm.nih.gov/pubmed/22006297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1110480108
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