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Conformational flexibility of ubiquitin-modified and SUMO-modified PCNA shown by full ensemble hybrid methods
Ubiquitin-modified PCNA (Ub-PCNA) and SUMO-modified PCNA (SUMO-PCNA) regulate DNA damage tolerance pathways. X-ray crystal structures of these proteins suggested that they do not have much conformational flexibility, because the modifiers have preferred binding sites on the surface of PCNA. By contr...
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| 出版年: | J Mol Biol |
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| 主要な著者: | , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6453135/ https://ncbi.nlm.nih.gov/pubmed/30381149 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2018.10.017 |
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