STRUCTURALLY DISTINCT UBIQUITIN- AND SUMO-MODIFIED PCNA: IMPLICATIONS FOR THEIR DISTINCT ROLES IN THE DNA DAMAGE RESPONSE

Proliferating cell nuclear antigen (PCNA) is a pivotal replication protein, which also controls cellular responses to DNA damage. Posttranslational modification of PCNA by SUMO and ubiquitin modulate these responses. How the modifiers alter PCNA-dependent DNA repair and damage tolerance pathways is...

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Publicado no:Structure
Main Authors: Tsutakawa, Susan E., Yan, Chunli, Xu, Xiaojun, Weinacht, Christopher P., Freudenthal, Bret D., Yang, Kun, Zhuang, Zhihao, Washington, M. Todd, Tainer, John A., Ivanov, Ivaylo
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394044/
https://ncbi.nlm.nih.gov/pubmed/25773143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2015.02.008
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