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Structure of Monoubiquitinated PCNA and Implications for Translesion Synthesis and DNA Polymerase Exchange

DNA synthesis by classical polymerases can be blocked by many lesions. These blocks are overcome by translesion synthesis, whereby the stalled classical, replicative polymerase is replaced by a non-classical polymerase. In eukaryotes, this polymerase exchange requires PCNA monoubiquitination. To bet...

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Detalhes bibliográficos
Main Authors: Freudenthal, Bret D., Gakhar, Lokesh, Ramaswamy, S., Washington, M. Todd
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2920209/
https://ncbi.nlm.nih.gov/pubmed/20305653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1776
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