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Structure and functional analysis of the BRCT domain of the translesion synthesis DNA polymerase Rev1 ()
Translesion synthesis (TLS) is a pathway in which specialized, low-fidelity DNA polymerases are used to overcome replication blocks caused by DNA damage. The use of this pathway often results in somatic mutations that can drive carcinogenesis. Rev1 is a TLS polymerase found in all eukaryotes that pl...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3580236/ https://ncbi.nlm.nih.gov/pubmed/23240687 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi301572z |
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