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PCNA trimer instability inhibits translesion synthesis by DNA polymerase η and by DNA polymerase δ

Translesion synthesis (TLS), the process by which DNA polymerases replicate through DNA lesions, is the source of most DNA damage-induced mutations. Sometimes TLS is carried out by replicative polymerases that have evolved to synthesize DNA on non-damaged templates. Most of the time, however, TLS is...

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שמור ב:
מידע ביבליוגרפי
Main Authors: Dieckman, Lynne M., Washington, M. Todd
פורמט: Artigo
שפה:Inglês
יצא לאור: 2013
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3636165/
https://ncbi.nlm.nih.gov/pubmed/23506842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2013.02.007
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