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PCNA trimer instability inhibits translesion synthesis by DNA polymerase η and by DNA polymerase δ
Translesion synthesis (TLS), the process by which DNA polymerases replicate through DNA lesions, is the source of most DNA damage-induced mutations. Sometimes TLS is carried out by replicative polymerases that have evolved to synthesize DNA on non-damaged templates. Most of the time, however, TLS is...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3636165/ https://ncbi.nlm.nih.gov/pubmed/23506842 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2013.02.007 |
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