Roles of PCNA-binding and ubiquitin-binding domains in human DNA polymerase η in translesion DNA synthesis

Treatment of yeast and human cells with DNA-damaging agents elicits Rad6–Rad18-mediated monoubiquitination of proliferating cell nuclear antigen (PCNA) at its Lys-164 residue [ubiquitin (Ub)-PCNA], and this PCNA modification is indispensable for promoting the access of translesion synthesis (TLS) po...

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Main Authors: Acharya, Narottam, Yoon, Jung-Hoon, Gali, Himabindu, Unk, Ildiko, Haracska, Lajos, Johnson, Robert E., Hurwitz, Jerard, Prakash, Louise, Prakash, Satya
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2584706/
https://ncbi.nlm.nih.gov/pubmed/19001268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0809844105
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