Solution X-ray scattering combined with computational modeling reveals multiple conformations of covalently bound ubiquitin on PCNA

PCNA ubiquitination in response to DNA damage leads to the recruitment of specialized translesion polymerases to the damage locus. This constitutes one of the initial steps in translesion synthesis (TLS)—a critical pathway for cell survival and for maintenance of genome stability. The recent crystal...

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Detalhes bibliográficos
Main Authors: Tsutakawa, Susan E., Van Wynsberghe, Adam W., Freudenthal, Bret D., Weinacht, Christopher P., Gakhar, Lokesh, Washington, M. Todd, Zhuang, Zhihao, Tainer, John A., Ivanov, Ivaylo
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3203759/
https://ncbi.nlm.nih.gov/pubmed/22006297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1110480108
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