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Conformational flexibility of fork-remodeling helicase Rad5 shown by full-ensemble hybrid methods

Several pathways exist to bypass DNA damage during replication. One such pathway is template switching. The Rad5 protein plays two important roles in template switching: it is an E3 ubiquitin ligase that catalyzes PCNA poly-ubiquitylation and it is a helicase that converts replication forks to chick...

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Bibliographic Details
Published in:PLoS One
Main Authors: Gildenberg, Melissa S., Washington, M. Todd
Format: Artigo
Language:Inglês
Published: Public Library of Science 2019
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6799953/
https://ncbi.nlm.nih.gov/pubmed/31626633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0223875
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