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Rad53 limits CMG helicase uncoupling from DNA synthesis at replication forks
The coordination of DNA unwinding and synthesis at replication forks promotes efficient and faithful replication of chromosomal DNA. Disruption of the balance between helicase and polymerase activities during replication stress leads to fork progression defects and activation of the Rad53 checkpoint...
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| Publicat a: | Nat Struct Mol Biol |
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| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7225081/ https://ncbi.nlm.nih.gov/pubmed/32341532 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-020-0407-7 |
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