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Rad53 limits CMG helicase uncoupling from DNA synthesis at replication forks

The coordination of DNA unwinding and synthesis at replication forks promotes efficient and faithful replication of chromosomal DNA. Disruption of the balance between helicase and polymerase activities during replication stress leads to fork progression defects and activation of the Rad53 checkpoint...

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Publicat a:Nat Struct Mol Biol
Autors principals: Devbhandari, Sujan, Remus, Dirk
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7225081/
https://ncbi.nlm.nih.gov/pubmed/32341532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-020-0407-7
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