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Rad53 limits CMG helicase uncoupling from DNA synthesis at replication forks
The coordination of DNA unwinding and synthesis at replication forks promotes efficient and faithful replication of chromosomal DNA. Disruption of the balance between helicase and polymerase activities during replication stress leads to fork progression defects and activation of the Rad53 checkpoint...
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| Publicado no: | Nat Struct Mol Biol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7225081/ https://ncbi.nlm.nih.gov/pubmed/32341532 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-020-0407-7 |
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