Checkpoint kinase Rad53 couples leading and lagging strand DNA synthesis under replication stress

The checkpoint kinase Rad53 is activated during replication stress to prevent fork collapse, an essential but poorly understood process. Here we show that Rad53 couples leading and lagging strand synthesis under replication stress. In rad53-1 cells stressed by dNTP depletion, the replicative DNA hel...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Mol Cell
Egile Nagusiak: Gan, Haiyun, Yu, Chuanhe, Devbhandari, Sujan, Sharma, Sushma, Han, Junhong, Chabes, Andrei, Remus, Dirk, Zhang, Zhiguo
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2017
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5802358/
https://ncbi.nlm.nih.gov/pubmed/29033319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.09.018
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