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Checkpoint kinase Rad53 couples leading and lagging strand DNA synthesis under replication stress
The checkpoint kinase Rad53 is activated during replication stress to prevent fork collapse, an essential but poorly understood process. Here we show that Rad53 couples leading and lagging strand synthesis under replication stress. In rad53-1 cells stressed by dNTP depletion, the replicative DNA hel...
שמור ב:
| הוצא לאור ב: | Mol Cell |
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| Main Authors: | , , , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2017
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5802358/ https://ncbi.nlm.nih.gov/pubmed/29033319 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.09.018 |
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