Strand-Specific Analysis Shows Protein Binding at Replication Forks and PCNA Unloading from Lagging Strands when Forks Stall

In eukaryotic cells, DNA replication proceeds with continuous synthesis of leading-strand DNA and discontinuous synthesis of lagging-strand DNA. Here we describe a method, eSPAN (enrichment and sequencing of protein-associated nascent DNA), which reveals the genome-wide association of proteins with...

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Vydáno v:Mol Cell
Hlavní autoři: Yu, Chuanhe, Gan, Haiyun, Han, Junhong, Zhou, Zhi-Xiong, Jia, Shaodong, Chabes, Andrei, Farrugia, Gianrico, Ordog, Tamas, Zhang, Zhiguo
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4362665/
https://ncbi.nlm.nih.gov/pubmed/25449133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.09.017
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