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Replication Fork Activation Is Enabled by a Single-Stranded DNA Gate in CMG Helicase
The eukaryotic replicative helicase CMG is a closed ring around double-stranded (ds) DNA at origins, yet must transition to single-stranded (ss) DNA for helicase action. CMG must also handle repair 18 intermediates such as reversed forks that lack ssDNA. Here, using correlative single-molecule 19 fl...
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| Publicado no: | Cell |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6705614/ https://ncbi.nlm.nih.gov/pubmed/31348887 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.06.032 |
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