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Structure of eukaryotic CMG helicase at a replication fork and implications to replisome architecture and origin initiation

The eukaryotic CMG (Cdc45, Mcm2–7, GINS) helicase consists of the Mcm2–7 hexameric ring along with five accessory factors. The Mcm2–7 heterohexamer, like other hexameric helicases, is shaped like a ring with two tiers, an N-tier ring composed of the N-terminal domains, and a C-tier of C-terminal dom...

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Bibliografiset tiedot
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Georgescu, Roxana, Yuan, Zuanning, Bai, Lin, de Luna Almeida Santos, Ruda, Sun, Jingchuan, Zhang, Dan, Yurieva, Olga, Li, Huilin, O’Donnell, Michael E.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2017
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5293012/
https://ncbi.nlm.nih.gov/pubmed/28096349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1620500114
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