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The eukaryotic CMG helicase at the replication fork: Emerging architecture reveals an unexpected mechanism

The eukaryotic helicase is an 11-subunit machine containing an Mcm2-7 motor ring that encircles DNA, Cdc45 and the GINS tetramer, referred to as CMG (Cdc45, Mcm2-7, GINS). CMG is “built” on DNA at origins in two steps. First, two Mcm2-7 rings are assembled around duplex DNA at origins in G1 phase, f...

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Detaylı Bibliyografya
Yayımlandı:Bioessays
Asıl Yazarlar: Li, Huilin, O’Donnell, Mike
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2018
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5873959/
https://ncbi.nlm.nih.gov/pubmed/29405332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bies.201700208
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