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Structure of the eukaryotic replicative CMG helicase and pumpjack motion
The CMG helicase is composed of Cdc45, Mcm2-7 and GINS. Here we report the structure of the S. cerevisiae CMG determined by cryo-EM at a resolution of 3.7–4.8 Å. The structure reveals that GINS and Cdc45 scaffold the N-tier of the helicase while enabling motion of the AAA+ C-tier. CMG exists in two...
Shranjeno v:
| izdano v: | Nat Struct Mol Biol |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2016
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4812828/ https://ncbi.nlm.nih.gov/pubmed/26854665 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3170 |
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