The Architecture of a Eukaryotic Replisome

At the eukaryotic DNA replication fork, it is widely believed that the Cdc45-Mcm2-7-GINS (CMG) helicase leads the way in front to unwind DNA, and that DNA polymerases (Pol) trail behind the helicase. Here we use single particle electron microscopy to directly image a replisome. Contrary to expectati...

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Gepubliceerd in:Nat Struct Mol Biol
Hoofdauteurs: Sun, Jingchuan, Shi, Yi, Georgescu, Roxana E., Yuan, Zuanning, Chait, Brian T., Li, Huilin, O’Donnell, Michael E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4849863/
https://ncbi.nlm.nih.gov/pubmed/26524492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3113
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