Structure of eukaryotic CMG helicase at a replication fork and implications to replisome architecture and origin initiation

The eukaryotic CMG (Cdc45, Mcm2–7, GINS) helicase consists of the Mcm2–7 hexameric ring along with five accessory factors. The Mcm2–7 heterohexamer, like other hexameric helicases, is shaped like a ring with two tiers, an N-tier ring composed of the N-terminal domains, and a C-tier of C-terminal dom...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Georgescu, Roxana, Yuan, Zuanning, Bai, Lin, de Luna Almeida Santos, Ruda, Sun, Jingchuan, Zhang, Dan, Yurieva, Olga, Li, Huilin, O’Donnell, Michael E.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2017
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5293012/
https://ncbi.nlm.nih.gov/pubmed/28096349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1620500114
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