Replication Fork Activation Is Enabled by a Single-Stranded DNA Gate in CMG Helicase

The eukaryotic replicative helicase CMG is a closed ring around double-stranded (ds) DNA at origins, yet must transition to single-stranded (ss) DNA for helicase action. CMG must also handle repair 18 intermediates such as reversed forks that lack ssDNA. Here, using correlative single-molecule 19 fl...

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Bibliographic Details
Published in:Cell
Main Authors: Wasserman, Michael R., Schauer, Grant D., O’Donnell, Michael E., Liu, Shixin
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6705614/
https://ncbi.nlm.nih.gov/pubmed/31348887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2019.06.032
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