Smac Mimetic Bypasses Apoptosis Resistance in FADD- or Caspase-8-Deficient Cells by Priming for Tumor Necrosis Factor α-Induced Necroptosis

Searching for new strategies to bypass apoptosis resistance, we investigated the potential of the Smac mimetic BV6 in Jurkat leukemia cells deficient in key molecules of the death receptor pathway. Here, we demonstrate for the first time that Smac mimetic primes apoptosis-resistant, FADD- or caspase...

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書誌詳細
主要な著者: Laukens, Bram, Jennewein, Claudia, Schenk, Barbara, Vanlangenakker, Nele, Schier, Alexander, Cristofanon, Silvia, Zobel, Kerry, Deshayes, Kurt, Vucic, Domagoj, Jeremias, Irmela, Bertrand, Mathieu JM, Vandenabeele, Peter, Fulda, Simone
フォーマット: Artigo
言語:Inglês
出版事項: Neoplasia Press Inc. 2011
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3201573/
https://ncbi.nlm.nih.gov/pubmed/22028622
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