Smac mimetic induces cell death in a large proportion of primary acute myeloid leukemia samples, which correlates with defined molecular markers

Apoptosis is deregulated in most, if not all, cancers, including hematological malignancies. Smac mimetics that antagonize Inhibitor of Apoptosis (IAP) proteins have so far largely been investigated in acute myeloid leukemia (AML) cell lines; however, little is yet known on the therapeutic potential...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Lueck, Sonja C., Russ, Annika C., Botzenhardt, Ursula, Schlenk, Richard F., Zobel, Kerry, Deshayes, Kurt, Vucic, Domagoj, Döhner, Hartmut, Döhner, Konstanze, Fulda, Simone, Bullinger, Lars
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2016
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5226527/
https://ncbi.nlm.nih.gov/pubmed/27385100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10390
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