Smac mimetic induces cell death in a large proportion of primary acute myeloid leukemia samples, which correlates with defined molecular markers

Apoptosis is deregulated in most, if not all, cancers, including hematological malignancies. Smac mimetics that antagonize Inhibitor of Apoptosis (IAP) proteins have so far largely been investigated in acute myeloid leukemia (AML) cell lines; however, little is yet known on the therapeutic potential...

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Dades bibliogràfiques
Publicat a:Oncotarget
Autors principals: Lueck, Sonja C., Russ, Annika C., Botzenhardt, Ursula, Schlenk, Richard F., Zobel, Kerry, Deshayes, Kurt, Vucic, Domagoj, Döhner, Hartmut, Döhner, Konstanze, Fulda, Simone, Bullinger, Lars
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2016
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5226527/
https://ncbi.nlm.nih.gov/pubmed/27385100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10390
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