Requirement of Nuclear Factor κB for Smac Mimetic-Mediated Sensitization of Pancreatic Carcinoma Cells for Gemcitabine-Induced Apoptosis

Defects in apoptosis contribute to treatment resistance and poor outcome of pancreatic cancer, calling for novel therapeutic strategies. Here, we provide the first evidence that nuclear factor (NF) κB is required for Smac mimetic-mediated sensitization of pancreatic carcinoma cells for gemcitabine-i...

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Main Authors: Stadel, Dominic, Cristofanon, Silvia, Abhari, Behnaz Ahangarian, Deshayes, Kurt, Zobel, Kerry, Vucic, Domagoj, Debatin, Klaus-Michael, Fulda, Simone
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press Inc. 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3257191/
https://ncbi.nlm.nih.gov/pubmed/22241962
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