A Bak-dependent mitochondrial amplification step contributes to Smac mimetic/glucocorticoid-induced necroptosis

Necroptosis is a form of programmed cell death that critically depends on RIP3 and MLKL. However, the contribution of mitochondria to necroptosis is still poorly understood. In the present study, we discovered that mitochondrial perturbations play a critical role in Smac mimetic/Dexamethasone (Dexa)...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Rohde, Katharina, Kleinesudeik, Lara, Roesler, Stefanie, Löwe, Oliver, Heidler, Juliana, Schröder, Katrin, Wittig, Ilka, Dröse, Stefan, Fulda, Simone
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5260489/
https://ncbi.nlm.nih.gov/pubmed/27834956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2016.102
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