A Bak-dependent mitochondrial amplification step contributes to Smac mimetic/glucocorticoid-induced necroptosis

Necroptosis is a form of programmed cell death that critically depends on RIP3 and MLKL. However, the contribution of mitochondria to necroptosis is still poorly understood. In the present study, we discovered that mitochondrial perturbations play a critical role in Smac mimetic/Dexamethasone (Dexa)...

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Bibliografische gegevens
Gepubliceerd in:Cell Death Differ
Hoofdauteurs: Rohde, Katharina, Kleinesudeik, Lara, Roesler, Stefanie, Löwe, Oliver, Heidler, Juliana, Schröder, Katrin, Wittig, Ilka, Dröse, Stefan, Fulda, Simone
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2017
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Original Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5260489/
https://ncbi.nlm.nih.gov/pubmed/27834956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2016.102
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