A Bak-dependent mitochondrial amplification step contributes to Smac mimetic/glucocorticoid-induced necroptosis

Necroptosis is a form of programmed cell death that critically depends on RIP3 and MLKL. However, the contribution of mitochondria to necroptosis is still poorly understood. In the present study, we discovered that mitochondrial perturbations play a critical role in Smac mimetic/Dexamethasone (Dexa)...

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Publicat a:Cell Death Differ
Autors principals: Rohde, Katharina, Kleinesudeik, Lara, Roesler, Stefanie, Löwe, Oliver, Heidler, Juliana, Schröder, Katrin, Wittig, Ilka, Dröse, Stefan, Fulda, Simone
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
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Original Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5260489/
https://ncbi.nlm.nih.gov/pubmed/27834956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2016.102
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