Smac Mimetic Bypasses Apoptosis Resistance in FADD- or Caspase-8-Deficient Cells by Priming for Tumor Necrosis Factor α-Induced Necroptosis

Searching for new strategies to bypass apoptosis resistance, we investigated the potential of the Smac mimetic BV6 in Jurkat leukemia cells deficient in key molecules of the death receptor pathway. Here, we demonstrate for the first time that Smac mimetic primes apoptosis-resistant, FADD- or caspase...

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Hlavní autoři: Laukens, Bram, Jennewein, Claudia, Schenk, Barbara, Vanlangenakker, Nele, Schier, Alexander, Cristofanon, Silvia, Zobel, Kerry, Deshayes, Kurt, Vucic, Domagoj, Jeremias, Irmela, Bertrand, Mathieu JM, Vandenabeele, Peter, Fulda, Simone
Médium: Artigo
Jazyk:Inglês
Vydáno: Neoplasia Press Inc. 2011
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3201573/
https://ncbi.nlm.nih.gov/pubmed/22028622
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